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Whole body glutamate and glutamine metabolism (click image) In the course of this second study, it came to our attention that there are large species and gender differences in the metabolism of APAP in the liver

A critical driver of AP pathogenesis was the dysregulated activation of the nucleotide oligomerization domain (NOD)-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome, a cytosolic multiprotein complex that orchestrates caspase-1-mediated maturation of pro-inflammatory cytokines interleukin-1 (IL-1) and IL-18, as well as gasdermin D (GSDMD)-dependent pyroptotic cell death (Ferrero-Andrs et al., 2020)

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Nat Med 2018;24:107080